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Thread: How about some good “world” news for once

  1. #1
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    How about some good “world” news for once

    ‘Unprecedented’, ‘Remarkable’: Cancer Study Leaves Every Patient Cancer-Free

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    Results from a small cancer trial that left every
    patient in remission is being praised as
    "unprecedented" and "remarkable."
    A paper published on Sunday at The New England
    Journal of Medicine outlined a study of 18 rectal
    cancer patients who were given dostarlimab every
    three weeks for six months and ended up cancer-
    free, including the first patient who is now two years
    out from the trial.
    "I believe this is the first time this has happened in
    the history of cancer," said Dr. Luis A. Diaz Jr. said,
    an author of the paper, The New York Times
    reported.
    Dr. Andrea Cercek, an oncologist at Memorial Sloan
    Kettering Cancer Center and another author of the
    paper, described "a lot of happy tears" at the end of
    the trial.
    While noting the study needs replication, Dr. Kimmie
    Ng, a colorectal cancer expert from the Dana-Farber
    Cancer Institute and an associate professor at
    Harvard University, called the trial results
    "remarkable" and "unprecedented."

    "We initiated a prospective phase 2 study in which
    single-agent dostarlimab, an anti-PD-1 monoclonal
    antibody, was administered every 3 weeks for 6
    months in patients with mismatch repair-deficient
    stage Il or Ill rectal adenocarcinoma," the study said.
    "This treatment was to be followed by standard
    chemoradiotherapy and surgery."
    Those who took the drug, which "unmasks cancer
    cells, allowing the immune system to identify and
    destroy them," according to the Times, did not have
    to move on to further cancer treatments.
    All the patients "had a clinical complete response,
    with no evidence of tumor on magnetic resonance
    imaging," the paper explained. "At the time of this
    report, no patients had received chemoradiotherapy
    or undergone surgery, and no cases of progression
    or recurrence had been reported during follow-up
    (range, 6 to 25 months). No adverse events of grade
    3 or higher have been reported."

    UNC Lineberger Comprehensive Cancer Center's
    Hanna K. Sanoff, MD, MPH, advised caution but said
    the findings were "very encouraging," according
    to Science Daily.
    "These initial findings of the remarkable benefit with
    the use of dostarlimab are very encouraging but also
    need to be viewed with caution until the results can
    be replicated in a larger and more diverse
    population," Sanoff said.
    "The responses in these first 12 of a planned-for 30
    patients in the trial were remarkable and exceed
    what we would expect with the standard
    chemotherapy plus radiation," she continued.
    "Although quality of life measures have not been
    reported yet, it's encouraging that some of the most
    difficult symptoms, such as pain and bleeding, all
    resolved with the use of dostarlimab."
    This post has been updated to note that Dr. Kimmie Ng
    is a colorectal cancer expert from the Dana-Farber
    Cancer Institute, as well as an associate professor at
    Harvard University

  3. #3
    Admin ZR's Avatar
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    Let's hope n pray results are correct.

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    Still early but hopeful results. Just hope similar treatments will also have an effect on other forms of cancer.

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    Off my meds again
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    Little late for those who've already lost loved ones...

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    Member Chinga's Avatar
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    Promising, but we all know it will only be buried. I've often said that they have/had a cure for Cancer in their pockets, but the business of Cancer treatment is far too big to let go.
    Member of the IDGAF+FU2 Community

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    Quote Originally Posted by Chinga View Post
    Promising, but we all know it will only be buried. I've often said that they have/had a cure for Cancer in their pockets, but the business of Cancer treatment is far too big to let go.
    It seems that way. I keep telling myself I hope it’s not true.

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